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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well-documented guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Disodium sulphide
EC Number:
215-211-5
EC Name:
Disodium sulphide
Cas Number:
1313-82-2
IUPAC Name:
disodium sulfide
Details on test material:
Name of the test substance used in the study report: Schwefelnatrium Schuppen 60%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
50, 150, 500, 5000 mg/kg
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
254 mg/kg bw
Mortality:
50 mg/kg - 0%; 150 mg/kg - 10%; 500 mg/kg - 90%; 5000 mg/kg - 100%
Clinical signs:
highest dose level: sedation, somnolence, dyspnea, ataxia, sluggished movements, lateral and abdominal position, ruffled fur

Applicant's summary and conclusion