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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic information given

Data source

Reference
Reference Type:
publication
Title:
Study of the genotoxic potential of 48 inorganic derivatives with the SOS chromotest.
Author:
Olivier, P.; Marzin, D.
Year:
1987
Bibliographic source:
Mutation Research 189, 263 - 269

Materials and methods

Principles of method if other than guideline:
The SOS Chromotest was performed as described by Quillardet et al. (1982), and adapted by Marzin et al. (1986).
GLP compliance:
no
Type of assay:
other: SOS chromotest

Test material

Constituent 1
Reference substance name:
Ammonium sulphide
EC Number:
235-223-4
EC Name:
Ammonium sulphide
Cas Number:
12135-76-1
IUPAC Name:
thioxoammonium
Details on test material:
Name of the test substance used in the publication: ammonium sulfide

Method

Target gene:
E. coli
Species / strain
Species / strain / cell type:
E. coli, other: PQ37 and PQ35
Metabolic activation:
with and without
Metabolic activation system:
rat liver S-9 mix
Test concentrations with justification for top dose:
0.9 - 9 mM/ml
Vehicle / solvent:
DMSO

Results and discussion

Test results
Species / strain:
E. coli, other: PQ37 and PQ35
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
valid
Untreated negative controls validity:
valid
Positive controls validity:
valid
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion