Registration Dossier
Registration Dossier
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EC number: 610-915-2 | CAS number: 52937-90-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- other information
- Rationale for reliability incl. deficiencies:
- other: Category Approach for three different 3-aminocrotonic acid esters, described in the 'Results and Discussion' section
Data source
Materials and methods
Results and discussion
Any other information on results incl. tables
Category Approach for three different 3-aminocrotonic acid esters
Testsystem |
- (CAS-No. 14205-39-1) |
- Isopropylester (CAS-No. 14205-46-0) |
- Isobutylester (CAS-No. 52937-90-3) |
Akut oral |
Classification with R 22/ Acute Tox 4 LD50:1760 mg/kg Results: 1300 mg without findings, ≥1500 narcosis, cyanosis, etc.; irritation in the stomach mucosa (Bayer internal report: Löser, 1983-06-30, T2015646) |
No classification LD50: > 2000 mg/kg Results: limit dose study; piloerection and diuresis up to 48 h after dosing (Bayer internal report: Bomhard, 1989-03-01, No. 17779) |
Classification with R 22 / Acute Tox 4 LD50:1400 mg/kg Results: 1000 mg without findings, ≥1300 mortality; narcosis, cyanosis, etc. irritation in the stomach mucosa (Bayer internal report: Ramm, 1985-11-12, No. T0020251) |
Akut inh. |
LC50 > 23 mg/m³ (dust; maximal technically feasible concentration) (Bayer internal report: Pauluhn, 1983-04-27, No. 11752) |
>6064 mg/m³ (aerosol) (Bayer internal report: Pauluhn, 1989-06-20, No. 18104) |
No data |
Skin irritation |
No classification Bayer report: Slight skin irritation (erythema grade 2, 24h; grade 1, 48h) Lonza report: No skin irritation (Bayer internal report: Schmidt, 1983-08-04, T5045748) |
No classification Slight skin irritation (erythema 0.3-1.0) (Bayer internal report: Märtins, 1989-03-20, No. 17843) |
No classification No data available Slight irritation expeced via category approach
|
Eye irritation |
Classification with R 41/ Eye Damage 1 Bayer report: Slight irritation (mean: cornea 0.3-0.7; erythema 1.3-2.0; chemosis 1.3-2.3) Lonza report: 1 animal with cornea grade 2 not reversible; animal 2 and 3: slight (Bayer internal report: Schmidt, 1983-08-03, T6015767) (Lonza report: Donald, 2000-03-23, No. 3202) |
Classification with R 36 / Eye Damage 2 Cornea grade 1-2, erythema grade 1-2, reversible (Bayer internal report: Märtins, 1989-03-20, No. 17843) |
Classification with R 36 / Eye Damage 2 No data available Eye irritation expeced via category aproach
|
Skin sensi |
Classification with R 43 / Skin sens 1 B Bayer report: M&K neg (paraffin; 5%, 12%, 1%; 1.challenge 3/10, 2. 1/10) Lonza report: M&K positive (maize oil, induction max. practicable conc.; challenge: max non-irritant conc. ; 4%, 60%, 60%; 10/10); QSAR toolbox predicts moderate skin sensitization potential (via Michael addition) (Bayer internal report: Stropp, 1997-08-07, No. 26525) (Lonza report: Donald, 2000-03-23, No. 3204) |
Classification with R 43/ Skin sens 1 B No animal data available QSAR toolbox predicts moderate skin sensitization potential (via Michael addition) Moderate skin sensitizing potential expected via category approach and QSAR
|
Classification with R 43 / Skin sens 1 B No animal data available QSAR toolbox predicts moderate skin sensitization potential (via Michael addition) Moderate skin sensitizing potential expected via category approach and QSAR
|
Ames Test (4 Salmonella strains) |
No classification Negativ (Bayer internal report: Herbold, 1986-01-07, No. 14189) |
No classification Negativ (Bayer internal report: Herbold, 1990-08-08, No. 19390 plus Amendment of 1994) |
No classification Negativ (Bayer internal report: Herbold, 1986-04-01, No. 14493) |
In vivo mouse bone marrow MNT |
No data |
Negativ (Bayer internal report: Herbold, 1990-05-29, No. 19096 plus Amendment of 1994) |
No data |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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