Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

NOEC (3 h): ≥ 1000 mg/L for the respiration of activated sludge microorganisms (OECD 209); read-across

Key value for chemical safety assessment

Additional information

No studies are available on the toxicity of Fatty acids, C12-16, esters with neopentyl glycol (CAS No. 85186-95-4) to microorganisms. The assessment was, therefore, based on a study conducted with the structurally similar category member heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5), as part of a read-across approach. This approach is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across. Further justification is given within the endpoint summary in IUCLID chapter 6.1 and within the category justification in IUCLID section 13.

The key study conducted with heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was performed as according to the OECD Guideline 209 and GLP (Roulstone, 2012). Activated sludge of a predominantly domestic sewage was exposed to the nominal test concentrations of 10, 100 and 1000 mg/L for 3 hours. No inhibition of the respiration rate of the activated sludge was observed. The respiration rate increased in all treatments, compared to the controls. The NOEC (3 h) was reported to be≥1000 mg/L.

Additionally, Fatty acids, C12-16, esters with neopentyl glycol is readily biodegradable (90.2% biodegradation in 28 days), which implies low toxicity to activated sludge microorganisms.

Thus, based on the above mentioned results, and due to the structural similarities and a consistent ecotoxicological/environmental fate profile of the substances, as explained with in the overall endpoint summary in IUCLID chapter 6.1, it can be concluded that the toxicity of Fatty acids, C12-16, esters with neopentyl glycol to aquatic microorganisms is very low. As it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results within the polyol esters category.

Categories Display