Registration Dossier
Registration Dossier
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EC number: 939-173-0 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
Test material
- Reference substance name:
- (3Z)-1-benzofuran-3(2H)-one O-methyloxime
- Cas Number:
- 208711-51-7
- Molecular formula:
- C9H9NO2
- IUPAC Name:
- (3Z)-1-benzofuran-3(2H)-one O-methyloxime
- Reference substance name:
- (3Z)-1-benzofuran-3(2H)-one O-methyloxime
- IUPAC Name:
- (3Z)-1-benzofuran-3(2H)-one O-methyloxime
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 24, 48, 72 hours
- Observation period (in vivo):
- 4 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: conjuct./redness
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- other: conjuct./chemosis
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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