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EC number: 634-657-5
CAS number: 65962-45-0
Acutely harmful to fish.
experimental data are available for
4,4'-diamino-3,3',5,5'-tetramethyldicyclohexylmethan (CAS 65962 -45 -0).
Therefore a read-across approach to two structurally similar substances
study was performed on 2,2'-dimethyl-4,4'-methylenebis(cyclohexylamin)
(CAS 6864-37-5) according to OECD 203 (NITE 2002) with Oryzias latipes.
The 96-LC50 was determined to be 22.4 mg/L, the NOEC was 16 mg/L and the
LC100 was 30 mg/L. The result is supported by a static-test study on CAS
6864-37-5 according to German industrial standard (DIN) 38412/15 (BASF
1988) performed with Leuciscus idus as test species. A 96-h LC50 of 31.6
mg/l was determined for non-neutralized samples (expressed as
geometrical mean). The NOEC was determined to be 21.5 mg/l and the LC100
46.4 mg/l. Because DMD changes the pH in water, a neutralized sample
with the highest test concentration (100 mg/l) was tested in addition.
For this neutralized sample a diminution of the toxic effects was
additional supporting study is a test performed on
4,4'-methylenebis-cyclohexanamine (CAS 1761-71-3) also performed
according to German Industrial Standard DIN 38412, Part 15 using
Leuciscus idus as test species (BASF AG, 1988; report no.
10F0562/875273). The 96 -h LC50 of 68.1 mg/L was determined for
non-neutralised samples. A neutralised sample lead to a significant
reduction of the mortality (96 -h LC50 > 100 mg/L).
conclusion, the toxic potential for
4,4'-diamino-3,3',5,5'-tetramethyldicyclohexylmethan (CAS 65962 -45 -0)
is assessed as acutely harmful to fish.
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