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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
6/2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
0.9
Temp.:
25 °C
pH:
7
Remarks on result:
other: mean value from 3 single values
Conclusions:
The partition coefficient (log pow) of the substance was 0.9 at 25 °C and pH 7.1.
Executive summary:

The partition coefficient was determined by using EU method A. 8 (HPLC method). The average log Pow of 0.9 was determined from 3 single values. In order to ensure a stable performance of the HPLC column, the column temperature was set to 40°C. However, the temperature of the log Pow of the test substance is dependent on the one of reference substance; and hence the determined log Pow is at 25°C.

Description of key information

The partition coefficient (log pow) of the substance was 0.9 at 25 °C and pH7.1

Key value for chemical safety assessment

Log Kow (Log Pow):
0.9
at the temperature of:
25 °C

Additional information