Registration Dossier

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Environmental and Human Safety of Major Surfactants: Alcohol Ethoxylates and Alkylphenol Ethoxylates
Author:
Talmage, S.S.
Year:
1994
Bibliographic source:
The Soap and Detergent Association, Lewis Publishers, Boca Raton.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved

Results and discussion

Any other information on results incl. tables

 NPE induced moderate to severe irritation. However, NPE with EO 10 and more induced no or slight irritation

Applicant's summary and conclusion