Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Environmental and Human Safety of Major Surfactants: Alcohol Ethoxylates and Alkylphenol Ethoxylates
Author:
Talmage, S.S.
Year:
1994
Bibliographic source:
The Soap and Detergent Association, Lewis Publishers, Boca Raton.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Amount / concentration applied:
0.1 mL

Results and discussion

Any other information on results incl. tables

in an eye irritation study of undiluted NPE solution at a dose of 0.1 mL, NPE solution was applied to the conjunctival sacs of New Zealand White rabbits and symptoms were observed. NPE with EO chain length of 2 to 15 induced moderate to severe irritation. NPE with EO chain length of 30 and more induced no irritation

Applicant's summary and conclusion

Interpretation of results:
other: NPE with EO chain length of 2 to 15 induced moderate to severe irritation. NPE with EO chain length of 30 and more induced no irritation