Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline study according to GLP principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- > 500 g/L
- Temp.:
- 20 °C
- pH:
- 4
- Water solubility:
- > 500 g/L
- Temp.:
- 20 °C
- pH:
- 7
- Water solubility:
- > 500 g/L
- Temp.:
- 20 °C
- pH:
- 9
- Details on results:
- Preliminary test results showes a solubility of > 1000 g/l.
In the main test three pH values was performed with five different test ite, concentrations in the resepective buffers. No correction of the pH values was performed. The mixtrure were incubated for approx. 24 h at 30 °C (300 rpm) and then equilibrated at 20 °C for 24 h. No phase sepration was oberved. The test item was completely dissolved in all samples. The pH values were checked.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The result of water solubility shows >500 g/L at 20°C and at pH 4, 7 and 9
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