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Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A reliable secondary source, summaring FEB pharmaco-toxicological properties, was used. However, the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used. The used secondary source has been updated on September, 2013; therefore it covers the most updated literature on the substance.
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 5 540 mg/kg bw
Based on:
other: Diphenylacetic acid
Clinical signs:
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ATAXIA
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 on rat is 5540 mg/kg.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A reliable secondary source, summaring FEB pharmaco-toxicological properties, was used. However, the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used. The used secondary source has been updated on September, 2013; therefore it covers the most updated literature on the substance.
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no
Species:
mouse
Strain:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
-
Doses:
-
No. of animals per sex per dose:
-
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 400 mg/kg bw
Based on:
other: Diphenylacetic acid
Mortality:
-
Clinical signs:
-
Body weight:
-
Gross pathology:
-
Other findings:
-
Interpretation of results:
other: inconclusive
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The LD50 by subcutaneous route is 400 mg/kg.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed

Additional information

Justification for classification or non-classification

Acute oral toxicity

No data were found for FEB in the scientific literature. As a result of read-across with Diphenylacetic acid LD50 by oral route is 5540 mg/kg on rat. Therefore, data are inconclusive for classification.

Acute dermal toxicity

No data were found for FEB in the scientific literature. As a result of read-across with Diphenylacetic acid LD50 by subcutaneous route is 400 mg/kg. Overall, data are inconclusive to classify this endpoint.

STOT SE (Specific target organ toxicity - single)

No data were found for FEB in the scientific literature. As a result of the acute toxicity test for a structural analogue of FEB, the animals showed changes in motor activity and behavioral disorder as ataxia. Overall, these data are judged as conclusive but not sufficient for classification.

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