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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A reliable secondary source, summaring FEB pharmaco-toxicological properties, was used. However, the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used. The used secondary source has been updated on September, 2013; therefore it covers the most updated literature on the substance.

Data source

Reference
Reference Type:
secondary source
Title:
Diphenylacetic acid
Bibliographic source:
CHEMID
Report date:
2013

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Reference substance name:
Diphenylacetic acid
EC Number:
204-185-0
EC Name:
Diphenylacetic acid
Cas Number:
117-34-0
IUPAC Name:
diphenylacetic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 500 mg/kg bw
Based on:
other: Diphenylacetic acid
Mortality:
-
Clinical signs:
-
Body weight:
-
Gross pathology:
-
Other findings:
-

Applicant's summary and conclusion

Conclusions:
The LD50 by intraperitoneal route is 500 mg/kg.

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