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Administrative data

Endpoint:
genetic toxicity in vitro
Remarks:
Type of genotoxicity: other: not applicable
Type of information:
(Q)SAR
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study results are disregarded as the substance is out of the the Applicability Domain (AD) of the model.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
publication
Title:
Mutagenicity
Author:
U.S. Environmental Protection
Bibliographic source:
T.E.S.T. v.4.1
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: General model for estimating the mutagenicity
Principles of method if other than guideline:
no data
GLP compliance:
no
Type of assay:
other: QSAR

Test material

Constituent 1
Chemical structure
Reference substance name:
o-phenethylbenzoic acid
EC Number:
225-511-8
EC Name:
o-phenethylbenzoic acid
Cas Number:
4890-85-1
Molecular formula:
C15H14O2
IUPAC Name:
2-(2-phenylethyl)benzoic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Results and discussion

Test results
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Remarks on result:
other: other: not applicable
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

Model assessment: Prediction is "mutagenicity = negative", but the result may be not reliable as only moderately similar compounds with known experimental value in the training set have been found.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

The obtained results are disregarded as the substance is out from the applicability domain of the model.

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