Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A reliable Local lymph node assay was performed on J-37 accoriding to OECD Guideline 429 ((NOTOX, 2010). Three experimental groups of five females CBA/J mice were treated with test substance concentration of 5, 10 or 25% w/w on three consecutive days, by open application on the ears. Five vehicle control animals were similarly treated, but with vehicle alone (Acetone/Olive(4:1 v/v)). Three days after the last exposure, all animals were injected with 3H-methyl thymidine and after five hours the draining (auricular lymph nodes were excised and pooled for each animal. After precipitating the DNA of the lymph node cells, radioactivity measurement was performed.
Mean DPM/animal values for the experimental groups treated with test substance concentrations 5, 10, and 25% were 417, 713 and 361 DPM respectively. The mean DPM/animal value for the vehicle control group was 509 DPM. The SI values calculated for the substance concentrations 5, 10 and 25% were 0.8, 1.4 and 0.7 respectively. Since there was no indication that the test substance could elicit an SI ≥3 when tested up to 25%, it was established that the EC3 value (the estimated test substance concentration that will give a SI=3) (if any) exceeds 25%.
Migrated from Short description of key information:
A key skin sensitisation study (LLNA) on J-37 showed no sensitisation potential to human skin.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
This information is not available.
Justification for classification or non-classification
According to DSD and CLP classification criteria for skin sensitisation, no classification is required for J-37.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
