Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The substance is not classified as irritating to skin but have a property of eye irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Maximization Pre-Test
GLP compliance:
not specified
Species:
human
Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
20% tricyclodecenyl acetate (13,800 lg/cm2) and 8% (5520 lg/cm2) in petrolatum were applied to the backs
Duration of treatment / exposure:
48 h
Number of animals:
35 and 26 healthy subjects
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 hr
Remarks on result:
other: DOSE : 20% ; No irritation
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48h
Remarks on result:
other: DOSE : 8% ; No irritation
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In maximization tests involving 35 and 26 healthy subjects, tested at 20% tricyclodecenyl acetate ( 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate) (13,800 lg/cm2) and 8% (5520 lg/cm2) in petrolatum it produced no irritation after a 48-hr.
Executive summary:

In maximization tests involving 35 and 26 healthy subjects, tested at 20% tricyclodecenyl acetate ( 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate) (13,800 lg/cm2) and 8% (5520 lg/cm2) in petrolatum it produced no irritation after a 48-hr.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard Draize test
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
other: Dose data : 6.25% , Moderately irritating
Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate is moderately irritating to rabbit eye at dose conc. of 6.25% .
Executive summary:

3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate is moderately irritating to rabbit eye at dose conc. of 6.25% .

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Skin irritation :

In maximization tests involving 35 and 26 healthy subjects, tested at 20% tricyclodecenyl acetate ( 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate) (13,800 lg/cm2) and 8% (5520 lg/cm2) in petrolatum it produced no irritation after a 48-hr.

Eye irritation :

3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate is moderately irritating to rabbit eye at dose conc.of 6.25% .


Justification for selection of skin irritation / corrosion endpoint:
In maximization tests involving 35 and 26 healthy subjects, tested at 20% tricyclodecenyl acetate ( 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate) (13,800 lg/cm2) and 8% (5520 lg/cm2) in petrolatum it produced no irritation after a 48-hr.

Justification for selection of eye irritation endpoint:
3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate is moderately irritating to rabbit eye at dose conc. of 6.25% .

Effects on eye irritation: moderately irritating

Justification for classification or non-classification