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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Fragrance material review on tricyclodecenyl acetate
Author:
S.P. Bhatia , L. Jones, C.S. Letizia, A.M. Api
Year:
2008
Bibliographic source:
Food and Chemical Toxicology 46 (2008) S56–S57

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from journal of Food and Chemical Toxicology
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
EC Number:
226-501-6
EC Name:
3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
Cas Number:
5413-60-5
Molecular formula:
C12H16O2
IUPAC Name:
3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
Test material form:
gas under pressure: refrigerated liquefied gas
Details on test material:
- Name of test material (as cited in study report): 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
- Substance type: Organic
- Physical state: Liquid

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: TA98, TA100, TA1535, TA1537, and TA1538
Additional strain / cell type characteristics:
not specified
Metabolic activation:
with and without
Metabolic activation system:
S9 liver fractions from Aroclor induced rats.
Test concentrations with justification for top dose:
0.00001 to 0.01 ug/plate
Vehicle / solvent:
dimethyl sulfoxide

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA98, TA100, TA1535, TA1537, and TA1538
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate (tricyclodecenyl acetate) gives negative results for gene mutation in Ames test conductedon S. typhimurium strains TA98, TA100,TA1535, TA1537, and TA1538 without metabolic activation.
Executive summary:

In an Ames test (Ames et al., 1975), 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate (tricyclodecenyl acetate), in dimethyl sulfoxide from doses 0.00001 to 0.01 ug/plate was not mutagenic in Salmonella typhimurium strains TA98, TA100,TA1535, TA1537, and TA1538 with and without addition of S9 liver fractions from Aroclor induced rats. Higher doses could not be tested due to bacteriostatic effects.

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