Registration Dossier
Registration Dossier
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EC number: 226-501-6 | CAS number: 5413-60-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material review on tricyclodecenyl acetate
- Author:
- S.P. Bhatia , L. Jones, C.S. Letizia, A.M. Api
- Year:
- 2 008
- Bibliographic source:
- Food and Chemical Toxicology 46 (2008) S56–S57
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from journal of Food and Chemical Toxicology
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
- EC Number:
- 226-501-6
- EC Name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
- Cas Number:
- 5413-60-5
- Molecular formula:
- C12H16O2
- IUPAC Name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material (as cited in study report): 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA98, TA100, TA1535, TA1537, and TA1538
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 liver fractions from Aroclor induced rats.
- Test concentrations with justification for top dose:
- 0.00001 to 0.01 ug/plate
- Vehicle / solvent:
- dimethyl sulfoxide
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA98, TA100, TA1535, TA1537, and TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate (tricyclodecenyl acetate) gives negative results for gene mutation in Ames test conductedon S. typhimurium strains TA98, TA100,TA1535, TA1537, and TA1538 without metabolic activation. - Executive summary:
In an Ames test (Ames et al., 1975), 3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate (tricyclodecenyl acetate), in dimethyl sulfoxide from doses 0.00001 to 0.01 ug/plate was not mutagenic in Salmonella typhimurium strains TA98, TA100,TA1535, TA1537, and TA1538 with and without addition of S9 liver fractions from Aroclor induced rats. Higher doses could not be tested due to bacteriostatic effects.
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