Registration Dossier
Registration Dossier
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EC number: 226-501-6 | CAS number: 5413-60-5
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: Parent fertility
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : DK6650000
- Author:
- RTECS Database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 57,466,1955
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenyl-p-benzoquinone
- EC Number:
- 206-654-5
- EC Name:
- Phenyl-p-benzoquinone
- Cas Number:
- 363-03-1
- IUPAC Name:
- 2-phenyl-1,4-benzoquinone
- Details on test material:
- - Name of test material (as cited in study report): phenyl-p-benzoquinone
- Substance type: Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Details on mating procedure:
- female 1 day(s) pre-mating
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 1 day(s)
- Control animals:
- not specified
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
Effect levels (P0)
- Dose descriptor:
- dose level: TDLo - Lowest published toxic dose
- Effect level:
- 5 mg/kg bw (total dose)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Toxic Effects : Reproductive - Maternal Effects - ovaries, fallopian tubes
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The toxicity (TDLo - Lowest published toxic dose) of phenyl-p-benzoquinone was tested in female rats by subcutaneous route shows effects as Reproductive - Maternal Effects - ovaries, fallopian tubes; if the dose concentration reaches upto 5 mg/kg bw (total dose).
- Executive summary:
The toxicity value for the target substance was not obtained for reproduction end point and so the same have been considered for a read across substance. The toxicity (TDLo - Lowest published toxic dose) of phenyl-p-benzoquinone was tested in female rats by subcutaneous route shows effects as Reproductive - Maternal Effects - ovaries, fallopian tubes; if the dose concentration reaches upto 5 mg/kg bw (total dose).
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