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Environmental fate & pathways

Hydrolysis

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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November December 2004
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 3-((1-(4-methylamino-3-nitrophenyl)methanoyl)pyridin-2-yl-amino)propionate
EC Number:
454-450-1
EC Name:
Ethyl 3-((1-(4-methylamino-3-nitrophenyl)methanoyl)pyridin-2-yl-amino)propionate
Cas Number:
429659-01-8
Molecular formula:
C18 H20 N4 O5
IUPAC Name:
ethyl 3-{1-[4-(methylamino)-3-nitrophenyl]-N-(pyridin-2-yl)formamido}propanoate
Test material form:
solid: particulate/powder
Radiolabelling:
no

Study design

Analytical monitoring:
not specified
Duration of test
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
100 µg/L
Positive controls:
no
Negative controls:
no

Results and discussion

Transformation products:
not specified
Dissipation DT50 of parent compoundopen allclose all
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
0.004 h-1
DT50:
184 h
Type:
not specified
pH:
9
Temp.:
40 °C
Hydrolysis rate constant:
0.02 h-1
DT50:
34 h
Type:
not specified
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
0.06 h-1
DT50:
12 h
Type:
not specified

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
From the experimental data obtained it can be concluded that the abiotic degradation hydrolysis if BIBR 1048 Manamide is significant only at ph 9 (> 10% in 5 days at 50 °C).