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Environmental fate & pathways

Biodegradation in water: screening tests

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Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
December 2004
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 3-((1-(4-methylamino-3-nitrophenyl)methanoyl)pyridin-2-yl-amino)propionate
EC Number:
454-450-1
EC Name:
Ethyl 3-((1-(4-methylamino-3-nitrophenyl)methanoyl)pyridin-2-yl-amino)propionate
Cas Number:
429659-01-8
Molecular formula:
C18 H20 N4 O5
IUPAC Name:
ethyl 3-{1-[4-(methylamino)-3-nitrophenyl]-N-(pyridin-2-yl)formamido}propanoate
Test material form:
solid: particulate/powder

Study design

Oxygen conditions:
not specified
Inoculum or test system:
activated sludge, domestic (adaptation not specified)
Duration of test (contact time):
28 d
Reference substance
Reference substance:
other: sodium benzoate

Results and discussion

% Degradationopen allclose all
Parameter:
% degradation (O2 consumption)
Value:
18
Sampling time:
28 d
Remarks on result:
other: without nitrification
Parameter:
% degradation (O2 consumption)
Value:
13
Sampling time:
28 d
Remarks on result:
other: with nitrification

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Interpretation of results:
not readily biodegradable
Conclusions:
BIBR 1048 Manamide was found to be slightly biodegradable under the test conditions within 28 days. However, the pass level for ready biodegradability, i.e. biodegradation of at least 60% of the ThOD (theoretical oxygen demand) in a 10-day window within the 28-day period of the test was not reached. Thus BIBR 1048 Manamide is not readily biodegradable.