Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
specific investigations: other studies
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Principles of method if other than guideline:
Test procedure:
OECD 429

Results and discussion

Details on results:
The results show that the test item (AE 0761014) has a
sensitizing potential in mice after dermal application.
Compared to vehicle treated animals there was a clear
increase regarding the weights of the draining lymph nodes
which is of statistical significance in the mid and the

high dose group and a clear increase in the cell counts in
all dose groups. These changes are of statistical
significance. The "positive level" of index 1.4 was exceeded
for the cell counts in all dose groups.


A significant increase compared to vehicle treated animals
regarding ear swelling was detected in the high dose group
and for ear weights in the mid and the high dose group. An
increase in this parameter do point to an acute irritating
(inflammatory) response. However, such an irritating
property is also combined with a strong skin sensitizing
potential of a test compound.


The results show that the test item has a sensitizing
potential in mice after dermal application.

Applicant's summary and conclusion