Registration Dossier
Registration Dossier
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EC number: 476-480-4 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Principles of method if other than guideline:
- Organisation for Economic Co-operation and Development
(OECD), OECD Guidelines for Testing of Chemicals, Section 4,
Health Effects. No.423, "Acute Oral Toxicity - Acute Toxic
Class Method", 2001
European Community (EC), Council Directive 67/548/EEC, Annex
V, Part B, Methods for the Determination of Toxicity, as
last amended by Commission Directive 2004/73/EC, B.1 tris:
"Acute Toxicity (Oral) - Acute Toxic Class Method", 2004.
United States Environmental Protection Agency (EPA). Health
Effects Test Guidelines, OPPTS 870.1100, Acute Oral
Toxicity. Office of Prevention, Pesticides and Toxic
Substances (7101), EPA 712-C-98-190, 2002.
Japanese Ministry of Agriculture, Forestry and Fisheries
(JMAFF), 12 Nousan, Notification No 8147, November 2000,
including the most recent partial revisions. - GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: Rat, Wistar strain Crl:WI
Administration / exposure
- Vehicle:
- other: None (The test substance was heated up to maximum of 40°C prior to dosing)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 429 mg/kg bw
- Mortality:
- Female: 2860 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 429 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: One female was found dead on Day 1 and two animals were sacrificed for ethical reasons on Day 2. No further mortality occurred. 2860 mg/kg bw: Lethargy, flat or hunched posture, uncoordinated movements, l
- Gross pathology:
- Effects on organs:
No abnormalities were found at macroscopic post mortem
examination of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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