Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Calculated log Pow= 6.24 at 25°C

Key value for chemical safety assessment

Log Kow (Log Pow):
6.24
at the temperature of:
25 °C

Additional information

The preliminary experiment carried out by the flask shaking method and yielded a log P > 5.26 This value shows that the expected P lies outside the range of the flask shaking method and must be estimated by the calculation method.

The calculation methods are described and discussed in the ANNEX of the Testing Guideline 117. They are all based on the formal fragmentation of the molecule into suitable substructures for which reliable log P increments are known.

The log Pow was calculated using Computer program CLOGP Release 3.42, Medicinal Chemistry Project, Pomona College, Claremont, Calif. 9171 which yielded a value of 7.2 (1992).

In the meantime (2017) there is improvement of the estimation software. Thus, the log Pow value has been reviewed and calculated using the common KOWWIN (v1.68) module of software EPI Suite v.4.11. The result given is considered reliable.