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Description of key information

The substance EC 401-280-0 hydrolyses in contact with water almost immediately. The proposed hydrolyses products are formaldehyde, bis(2-ethylhexylamine) and 1H-1,2,4-triazole.

Hydrolysis of formaldehyde and bis(2-ethylhexyl)amine is not expected due ot their chemical structure. The hydrolysis half-life of 1H-1,2,4-triazole is > 30days.

Key value for chemical safety assessment

Additional information

Parent substance EC 401 -280 -0

The results of the Hydrolysis study (Ciba, 2009) show that the test item hydrolyzes rapidly in water. The proposed degradation products are bis(2-ethylhexyl)amine, 1H-1,2,4-triazole and formaldehyde. The study includes to sets of experiments:

1st experiment: Investigation by LC/MS showed one sharp peak which is identical with a degradation product of the test item. This proves that the test item hydrolysis almost instantly, when it comes into contact with the aqueous eluent of the HPLC.

2nd experiment: Investigation by H-NMR showed that solutions of the test item are stable in pure acetonitrile for at least 20 h. Immediately after addition of D2O degradation products of the test item occured. The experiments prove that hydrolysis of test item, even with small amounts of water, is very fast.

hydrolysis products:

bis(2 -ethyhexyl)amine

The structure of the substance does not contain any functional groups sensitive to hydrolysis


Hydrolysis is not expected

1H-1,2,4 -triazole

Data with 1,2,4-triazole show that hydrolysis half-life was not observed during 30days, therefore the half-life is > 30days.