Registration Dossier
Registration Dossier
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EC number: 940-679-9 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No data on chronic toxicity to fish is available for H250 sulphonic acid. Data from Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts (LABS Na) as structural analogue was used to understand the chronic toxicity profile of substance to fish. The 72-day NOEC for fish of test substance was 0.23 mg/L .
Key value for chemical safety assessment
Additional information
Benzenesulphonic acid, dimethyl-,mono C14-16-alkyl derivative (H250 sulphonic acid) is a UVCB. Based on structural and functional similarities, data on Benzenesulphonic acid, 4-C10-13-sec-alkyl derivatives (LABS; CAS no: 85536-14-7) being registered under REACH, LABS Na (CAS no: 68411-30-3) being registered under REACH and LAB (CAS no: 67774-74-7) being registered under REACH are suitable as supporting study in case where specific data on the substance is lacking.
There is no chronic fish study available with H250 sulphonic acid. The study from Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts (LABS Na) as structural analogue was used to cover this endpoint.
Fertilized eggs of Salmo gairdneri were exposed to LABS in concentrations of 0.03, 0.23, 0.35, 0.63, 0.95 and 1.9 mg/L (mean measured), for 72 days. The responses recorded included the survival of eggs, time to eyed egg stage, time to hatch, survival and final weight of sac-fry (eleutheroembryos), time and extent of swim-up (external feeding). The lowest NOEC value found was 0.23 mg/L based on survival of eggs exposed from eyed stage, survival of eggs exposed from fertilization, survival of sac fry, and overall survival from fertilization to swim-up.
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