Registration Dossier
Registration Dossier
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EC number: 457-940-3 | CAS number: 183065-68-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August/September 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD and GLP guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.5
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-bromo-2,6-difluorobenzoic acid
- EC Number:
- 457-940-3
- EC Name:
- 4-bromo-2,6-difluorobenzoic acid
- Cas Number:
- 183065-68-1
- Molecular formula:
- Hill formula: C7H3BrF2O2 CAS formula: C7H3BrF2O2
- IUPAC Name:
- 4-bromo-2,6-difluorobenzoic acid
- Details on test material:
- Nature of substance: solid
Constituent 1
Test animals / tissue source
- Species:
- other: rbt, Crl:KBL(NZW)BR
Test system
- Amount / concentration applied:
- 100 MG
- Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: over 72 h
- Score:
- 1.33
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: over 72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: over 72 h
- Score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: over 72 h
- Score:
- 1
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Executive summary:
The eye irritation potential of 4-Bromo-2,6-difluorobenzoic acid was tested according to OECD 405. The test was conducted with one rabbit. The following mean scores were determined over the first 72 h: cornea: 1.33, iris: 0, conjunctivae: 2.00, chemosis: 1.00. After day 18 the irritation had completely resolved.
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