N,N-dimethyl-p-toluidine

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report was prepared based on two hydrolysis studies.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

yes

Remarks:

WoE 3

Temp.:

25 °C

Remarks:

WoE 2. The study was performed at pH 4, 7 and 9, respectively.

Duration:

5 d

Temp.:

50 °C

Initial conc. measured:

20 mg/L

Remarks:

WoE 3. The study was performed at pH 4, 7 and 9, respectively.

Number of replicates:

WoE 2. No data available
WoE 3. 2 replicates/pH solution

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

Key result

Temp.:

25 °C

DT50:

> 1 yr

Remarks on result:

other: WoE 2. The study was performed at pH 4, 7 and 9, respectively.

Temp.:

50 °C

Remarks on result:

other: WoE 3. Although the half-life value of test chemical was not known, but at the preliminary test, the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water.

Details on results:

WoE 2. The half-life value of test chemical was determined to be > 1 yr at pH 4, 7 and 9, respectively at a temperature of 25⁰C. Thus, the test chemical was reported to be hydrolytically stable.
WoE 3. The residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and at a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical was non hydrolysable in water.

Executive summary:

Data from various sources for the test chemical were reviewed for the hydrolysis end point study which are summarized as below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH of 4, 7 and 9, respectively. The half-life value of test chemical was determined to be > 1 yr at pH 4, 7 and 9, respectively at a temperature of 25⁰ C. Thus, based on this result, test chemical was considered to be non-hydrolysable.

 

Above data further supported by the data obtained from the secondary sources. The half-life of the test chemical was determined at different pH range. The preliminary study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Initial test chemical concentration used for the study was 20 mg/l. Analytical method involve the use of HPLC. Although the half-life value of test chemical was not known, but at the preliminary test, the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50 ⁰ C and at pH 4, 7 and 9, respectively. Based on the half-life values, it was concluded that the test chemical was non hydrolysable.

 

Thus, based on the above all studies and result observation, test chemical was considered to be non-hydrolysable.  

Description of key information

On the basis of the experimental studies and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 1 yr, at pH range 4, 7 & 9 and at a temperature of 25°C or 50°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical was non hydrolysable in water.

Additional information

Data from various sources for the test chemical and structurally and functionally similar read across chemicals were reviewed for the hydrolysis end point study which are summarized as below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH of 4, 7 and 9, respectively. The half-life value of test chemical was determined to be > 1 yr at pH 4, 7 and 9, respectively at a temperature of 25⁰ C. Thus, based on this result, test chemical was considered to be non-hydrolysable.

 

Above data further supported by the data obtained from the secondary sources. The half-life of the test chemical was determined at different pH range. The preliminary study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Initial test chemical concentration used for the study was 20 mg/l. Analytical method involve the use of HPLC. Although the half-life value of test chemical was not known, but at the preliminary test, the residues of the test chemical were more than 90 % in all the pH. Thus, the test chemical was reported to be stable in water at a temperature of 50 ⁰ C and at pH 4, 7 and 9, respectively. Based on the half-life values, it was concluded that the test chemical was non hydrolysable.

 

Thus, based on the above all studies and result observation, test chemical was considered to be non-hydrolysable.