Registration Dossier
Registration Dossier
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EC number: 202-805-4 | CAS number: 99-97-8
Toxicological information
Toxicological Summary
Currently viewing:
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.128 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Dose descriptor starting point:
- NOAEC
- Value:
- 19.1 mg/m³
- Value:
- 9.6 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.624 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Dose descriptor starting point:
- NOAEL
- Value:
- 44.6 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 62.4 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Sensitive Species has been selected
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 22.7 µg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Dose descriptor starting point:
- NOAEC
- Value:
- 19.1 mg/m³
- Value:
- 3.41 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.223 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Dose descriptor starting point:
- NOAEL
- Value:
- 44.6 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 44.6 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Sensitive Species has been selected
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 µg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Dose descriptor starting point:
- LOAEL
- Value:
- 6 mg/kg bw/day
- Value:
- 6 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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