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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
466-280-5
EC Name:
-
Cas Number:
67643-70-3
Molecular formula:
C13H23NO2
IUPAC Name:
3,7-dimethylocta-1,6-dien-3-yl N,N-dimethylcarbamate
Details on test material:
Batch No. 9000575061
Purity: 97.4%

Test animals

Species:
rat
Strain:
other: HanBri: Wist
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Remarks:
PEG 300
Doses:
single dose 2000 mg/kg body weight
No. of animals per sex per dose:
2 groups each of three females
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The median lethal dose of GR-86-0999 after single oral admisnistration to female rats observed over a period of 14 days is:
LD50 (female rat): greater than 2000 mg/Kg body weight