Registration Dossier
Registration Dossier
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EC number: 478-670-2 | CAS number: 139306-10-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Principles of method if other than guideline:
- Organisation for Economic Co-operation and Development
(OECD), OECD Guidelines for Testing of Chemicals, Section 4,
Health Effects. No.423, "Acute Oral Toxicity - Acute Toxic
Class Method", 2001
European Community (EC), Council Directive 67/548/EEC, Annex
V, Part B, Methods for the Determination of Toxicity, as
last amended by Commission Directive 2004/73/EC, B.1 tris:
"Acute Toxicity (Oral) - Acute Toxic Class Method", 2004.
United States Environmental Protection Agency (EPA). Health
Effects Test Guidelines, OPPTS 870.1100, Acute Oral
Toxicity. Office of Prevention, Pesticides and Toxic
Substances (7101), EPA 712-C-98-190, 2002.
Japanese Ministry of Agriculture, Forestry and Fisheries
(JMAFF), 12 Nousan, Notification No 8147, November 2000,
including the most recent partial revisions. - GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: Rat, Wistar strain Crl:WI(Han)
Administration / exposure
- Vehicle:
- propylene glycol
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 2
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Two females treated at 2000 mg/kg were found dead on Day 1. No further mortality occurred at 2000 and 300 mg/kg. 2000 mg/kg: Hunched posture, uncoordinated movements, quick breathing, piloerection.
- Gross pathology:
- Effects on organs:
At macroscopic post mortem examination, dark red
discolouration of glandular mucosa of the stomach was found
in the animals that died during the study. Macroscopic post
mortem examination of the surviving animals at termination
did not reveal any abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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