Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 410-560-1 | CAS number: 153519-44-9 CGL 400
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Based on the long-term (chronic) toxicity study data, the test substance is very likely not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
A GLP guideline study according OECD 211 including analytical monitoring has been conducted (BASF SE 2015). Due to the low solubility of the test substance the test solutions were prepared following general guidance provided in OECD 23 in order to achieve a saturated solution (water saturated fraction, WSF) of the test substance. The test solutions were weighed in and prepared separately (differential loading).
After 22 d no significant mortality, reduced reproduction or any other additional significant adverse effects or abnormal behavior were observed in any of the test treatments. Therefore, the LOEC was determined to be > 10 mg/L (loading rate) and the NOEC was determined to be ≥ 10 mg/L (loading rate).
Concerning analytical monitoring, no test substance peaks were measured in any of the control samples over the exposure period. Peaks corresponding to the test substance were measured in many of the samples from the treatments groups, but many others were below the wLOQ. Results were inconsistent and varied widely both within and between treatment groups. There was no pattern of increasing measured concentration corresponding to the loading rate. The measured concentrations do confirm the presence of the test substance in the test vessels, however they are not suitable to derive exposure levels due to the high variability. Since all reasonable efforts were taken to produce saturated solutions of the test substance in test media, following the guidance in OECD 23, the test results should be based on loading rate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
