Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
GLP compliance:
no
Other quality assurance:
other: Univerzita Pardubice, Fakulta chemicko-technologická - performs expertises inter alia in the field of physical chemistry
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
5-bromonicotinic acid
EC Number:
244-065-5
EC Name:
5-bromonicotinic acid
Cas Number:
20826-04-4
Molecular formula:
C6H4BrNO2
IUPAC Name:
5-bromonicotinic acid
Test material form:
solid: particulate/powder

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
>= 1.17 - <= 1.29
Temp.:
23.5 °C
pH:
6.4

Applicant's summary and conclusion

Executive summary:

Partition coefficient of the registered substance in system water/n-octanol is 17.04 ± 2.16 or as log Pow: 1.23 ± 0.06.