Registration Dossier

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
December 09-12, 1986
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EPA primary dermal irritation in rabbits (40 CFR section 798.4470)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
419-690-3
EC Name:
-
Cas Number:
88020-55-7
Molecular formula:
[(C12H25)3NH]4Mo8O26
IUPAC Name:
tridodecylamine hydrate molybdenum

Test animals

Species:
rabbit
Strain:
other: New Zealander albino Rabbits

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
other: None , a gauze patch wa placed and moistene with 0.5 ml of distilled water
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 h
Observation period:
30-60 minutes after patch removal
24-48-72 hours after patch removal
Number of animals:
6 rabbits (young adults)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 0 d; Max. value at end of observation period: 0
Irritation parameter:
edema score
Basis:
mean
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 0 d; Max. value at end of observation period: 0
Other effects:
none

Any other information on results incl. tables

Overall results (showing mean scores if > 3 animals) : calculated on the basis of the scores for each animal at 24, 48 and 72 hours

Applicant's summary and conclusion

Interpretation of results:
other: not classified