Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

A published study on lipid metabolism after repeated subcutaneous dosing of Ethyl trichloroacetate was available; the study was not meant for regulatory purpose and did not follow test guidelines, therefore it was taken up for completeness, but disregarded for classification.

Rats maintained on a choline deficient diet and treated with subcutaneous doses of ethyl trichloroacetate responded by increasing plasma β-lipoprotein and plasma triglyceride levels while excess triglyceride was being removed from the liver. There was a transient depression in plasma phospholipid at the beginning of the treatment. Continued administration of ethyl trichloroacetate raised plasma triglyceride in choline depleted rats and raised hepatic phospholipid concentration in both choline deficient and supplemented rats.
It is suggested that the lipotropic action of ethyl trichloroacetate occurs through hepatic triglyceride being removed by the altered plasma lipids and not by inhibition of hepatic triglyceride synthesis.

Justification for classification or non-classification