Registration Dossier
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EC number: 275-639-3 | CAS number: 71566-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (At test ending, the survivors were not subjected to necropsy and pathological examination. )
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Diisopropyl 3,3'-[(2,5-dichloro-1,4-phenylene)bis[iminocarbonyl(2-hydroxy-3,1-naphthylene)azo]]bis[4-methylbenzoate]
- EC Number:
- 275-639-3
- EC Name:
- Diisopropyl 3,3'-[(2,5-dichloro-1,4-phenylene)bis[iminocarbonyl(2-hydroxy-3,1-naphthylene)azo]]bis[4-methylbenzoate]
- Cas Number:
- 71566-54-6
- Molecular formula:
- C50 H42 Cl2 N6 O8
- IUPAC Name:
- propan-2-yl 3-[(Z)-2-{3-[(2,5-dichloro-4-{3-hydroxy-4-[(Z)-2-{2-methyl-5-[(propan-2-yloxy)carbonyl]phenyl}diazen-1-yl]naphthalene-2-amido}phenyl)carbamoyl]-2-hydroxynaphthalen-1-yl}diazen-1-yl]-4-methylbenzoate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Physical state: red powder
- Analytical purity: no data
- Lot/batch No.: 7/83
- No further data provided
Constituent 1
- Specific details on test material used for the study:
- - Physical state: red powder
- Analytical purity: no data
- Lot/batch No.: 7/83
- No further data provided
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CERJ, 53940 Le Genest.
- Weight at study initiation: 220 - 250 g for males; 170 - 200 g for females
- Fasting period before study: yes, 18 hours
- Housing: 10 animals per cage (Makrolon SAFI cages, 60 x 40 cm)
- Diet (e.g. ad libitum): UAR A04 Diet, ad libitum
- Water (e.g. ad libitum): Tap water, ad libitum
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 21 °C
- Humidity (%): 40 - 60 %
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 hrs/12 hrs
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- - Concentration in vehicle: 25 g of test material in 100 mL vehicle
- Application volume:: 2 mL/100 g body weight - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the animals were continuously observed for mortality and clinical symptoms; body weights were recored at test initiation (prior to treatment), on day 7 and on day 14 of observation.
- Necropsy and pathological examination were scheduled for animals found dead during the first 8 hours following treatment.
- No necropsy of survivors was scheduled.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: neither mortality nor clinical signs indicative of toxicity were observed during the 14-day observation period.
- Mortality:
- All animals survived.
- Clinical signs:
- Immediately following application, piloerection and apathy were observed; these symptoms however disappeared rapidly during the course of the observation period.
- Body weight:
- Body weight change in the course of the study was inconspicuous.
- Gross pathology:
- Since no animal died, no necrospy and thus, no gross pathology was conducted.
Any other information on results incl. tables
Mean body weight recorded for male and female Wistar rats following single gavage with 5000 mg/kg bw of the test material:
Animals (N = 5/sex) | Day 0 | Day 7 | Day 14 | |
Males | Treated | 218.5 g | 265.5 g | 284 g |
Untreated* | 231 g | 267 g | 290 g | |
Females | Treated | 177 g | 206 g | 209 g |
Untreated* | 190 g | 207 g | 207 g | |
Untreated*, vehicle only |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
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