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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited data given. Deficiencies: - no detailed information on animals, husbandry, performance of the test, test substance, cageside/clinical observations - only 1 animal per dose group

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
(no detailed information on animals, husbandry, performance of the test, test substance, cageside/clinical observations; only 1 animal per dose group)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Batch No.: 2511/72
No further details.
Specific details on test material used for the study:
- Batch No.: 2511/72
- Physical state: Red powder

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3.08, 2.88, 2,70 kg
No further details.

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
TEST SITE
The skin at the site of application was abraded.
Duration of exposure:
No data.
Doses:
300, 1000, 3000 mg/kg
No. of animals per sex per dose:
1
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of weighing: day 1, 7, 14
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: neither mortality nor clinical signs indicative of toxicity were observed during the 14-day observation period.
Mortality:
No animal died.
Clinical signs:
No pharmacotoxic symptoms were observed in any of the rabbits following dermal exposure to the test material.
Body weight:
Animal 1: Day1/7/14: 3.08/3.16/3.28 kg
Animal 2: Day1/7/14: 2.88/2.82/3.12 kg
Animal 3: Day1/7/14: 2.70/2.80/2.90 kg
Gross pathology:
Necropsy examination of all rabbits at the end of the 14-day observation period did not reveal any gross pathologic alterations.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information