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EC number: 275-639-3 | CAS number: 71566-54-6
Pigment Red 221 did not cause skin sensitization in the guinea pig maximization test (OECD 406) (Ciba-Geigy 1986).
After occlusive epicutaneous administration, no skin reactions were found in the control and test groups.
Pigment Red 221 (CAS 71566-54-6, 926 g/mol)
Pigment Red 221 was tested in a GLP compliant guinea pig maximization test following OECD testing guideline 406 (Ciba-Geigy Ltd 1986a). A concentration of 1% was used for intradermal application in a sesame oil and saline adjuvant mixture. 30% was used for epidermal application (Induction) in vaseline. For challenge exposure, 10% in vaseline was applied. The test was performed on 10 male and 10 female guinea pigs per group. At the concentration of 10% in vaseline, Pigment Red 221 did neither induce edema nor erythema reactions after epidermal challenge application and was therefore found to be non skin sensitizing.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for skin sensitization under Regulation (EC) No. 1272/2008, as amended for the thirteenth time in Regulation (EC) No. 2018/1480.
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