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EC number: 214-688-7 | CAS number: 1185-81-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- In-life dates: 24th August to 29th September 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dibutylbis(dodecylthio)stannane
- EC Number:
- 214-688-7
- EC Name:
- Dibutylbis(dodecylthio)stannane
- Cas Number:
- 1185-81-5
- Molecular formula:
- C32H68S2Sn
- IUPAC Name:
- dibutylbis(dodecylsulfanyl)stannane
- Details on test material:
- - Name of test material (as cited in study report): Dabco T120 Catalyst
- Analytical purity: 100%
- Lot/batch No.: 817231
- Physical state: clear liquid
- Stability under test conditions: stable
- Storage condition of test material: room temperature
- Date recieved: 13/08/2010
- Specific gravity: 1.00
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animals were received from Ace Animals, Boyertown, PA on 08/03/10 & 09/07/10 and from Taconic Farms, Hudson, NY on 08/17/10
- Age at study initiation: The animals were born the weeks of 06/08/10, 06/21/10, 06/28/10 & 07/20/10.
- Weight at study initiation: The pretest body weight range was 208 - 275 grams for males and 212 - 264 grams for females.
- Fasting period before study: 16-20 hours prior to dosing
- Housing: The animals were identified by cage notation and indelible body marks, and housed in suspended wire cages; 5/sex/cage prior to dosing and 3/sex/cage following dosing. Paper bedding was placed beneath the cages and changed at least three times/week.
- Diet (e.g. ad libitum): Fresh PMI Rat Chow (Diet #5012) was freely available except for 16-20 hours prior to dosing.
- Water (e.g. ad libitum): Water was available ad libitum.
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
The animal room, reserved exclusively for rats on acute tests, was temperature controlled, had a 12 hour light/dark cycle, and was kept clean and vermin free.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: The test article was used as received and the dose was based on the sample weight as calculated from the specific gravity. - Doses:
- Initially, a single dose was administered orally by syringe and dosing needle at a dose level of 300 mg/kg to three male and three female rats. Since the animals survived, an additional three male and three female rats were dosed at a dose level of 2000 mg/kg.
- No. of animals per sex per dose:
- 3 males & 3 females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed 0.5, 1, 2, 3 and 4 hours postdose and once daily for 14 days for mortality, toxicity and pharmacological effects. Body weights were recorded immediately pretest, weekly and at termination.
- Necropsy of survivors performed: yes
- Other examinations performed: All animals were humanely sacrificed using CO2 and were examined for gross pathology following study termination. - Statistics:
- no data
Results and discussion
- Preliminary study:
- n/a
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All six animals survived the single 300 and 2000 mg/kg oral doses.
- Clinical signs:
- other: In the 300 mg/kg dose animals, chromodacryorrhea was briefly noted in one animal; otherwise no abnormal physical signs were noted. In the 2000 mg/kg dose animals, instances of localized alopecia and soiling of the anogenital area were observed during th
- Gross pathology:
- In the 300 mg/kg dose animals, necropsy results revealed chromodacryorrhea in one animal and all other animals were normal.
In the 2000 mg/kg dose animals, aside from localized alopecia, the necropsy results were normal.
Any other information on results incl. tables
Table 1. Dose volume and Body weights.
Animal number | Sex | Dose Volume (cc) | Bodyweight (g) | ||
Day 0 | Day 7 | Day 14 | |||
Dose: 300mg/kg | |||||
1 | F | 0.069 | 230 | 283 | 290 |
2 | F | 0.071 | 235 | 276 | 292 |
3 | F | 0.079 | 264 | 305 | 328 |
Mean | 243 | 288 | 303 | ||
S.D. | 18.4 | 15.1 | 21.4 | ||
# | 3 | 3 | 3 | ||
4 | M | 0.075 | 250 | 297 | 320 |
5 | M | 0.08 | 265 | 322 | 345 |
6 | M | 0.083 | 275 | 304 | 368 |
Mean | 263 | 308 | 344 | ||
S.D. | 12.6 | 12.9 | 24 | ||
# | 3 | 3 | 3 | ||
Dose: 2000 mg/kg | |||||
7 | F | 0.49 | 246 | 266 | 278 |
8 | F | 0.42 | 212 | 237 | 245 |
9 | F | 0.43 | 216 | 230 | 241 |
Mean | 225 | 244 | 255 | ||
S.D. | 18.6 | 19.1 | 20.3 | ||
# | 3 | 3 | 3 | ||
10 | M | 0.43 | 215 | 262 | 343 |
11 | M | 0.44 | 222 | 211 | 288 |
12 | M | 0.42 | 208 | 282 | 343 |
Mean | 215 | 252 | 325 | ||
S.D. | 7 | 36.6 | 31.8 | ||
# | 3 | 3 | 3 |
S.D. = Standard deviation
# = number of animals
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was determined to be greater than 2000 mg/kg of body weight in rats.
- Executive summary:
A study was conducted to determine the potential for oral toxicity using the Acute Toxic Class Determination. This study is designed to comply with the standards set forth in OECD Guidelines for the Testing of Chemicals, Guideline 423 adopted December 17, 2001. Guideline 423 is referred to in OPPTS 870,1000 (December 2002) as an acceptable method to assess lethality within a dose range.
Initially, three healthy male and three healthy female Sprague Dawley rats were dosed orally with the test material at 300 mg/kg. Since the animals survived, an additional three male and three female rats were dosed at a dose level of 2000 mg/kg. The rats were observed 0.5, 1, 2, 3 and 4 hours postdose and once daily for 14 days for mortality, toxicity and pharmacological effects. Body weights were recorded immediately pretest, weekly and at termination. All animals were examined for gross pathology. The test article was assigned to a toxic category based on the mortality response noted.
All six animals survived the single 300 mg/kg oral dose. Chromodacryorrhea was briefly noted in one animal; otherwise no abnormal physical signs were noted. Body weight changes were normal, Necropsy results revealed chromodacryorrhea in one animal and all other animals were normal.
All six animals survived the single 2000 mg/kg oral dose. Instances of localized alopecia and soiling of the anogenital area were observed during the observation period. Body weight changes were normal in 5/6 animals; one male lost weight within the first week of observations. Aside from localized alopecia, the necropsy results were normal.
The test material is considered to be in Acute Toxic Category 5 or unclassified. The LD50 is greater than 2000 mg/kg of body weight in rats.
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