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EC number: 203-585-2 | CAS number: 108-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study; Not GLP
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits.
- Author:
- Flickinger, C.W.
- Year:
- 1 976
- Bibliographic source:
- American Industrial Hygiene Association Journal, 37:596-606.
- Report date:
- 1976
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FHSLA
- Principles of method if other than guideline:
- Method: other: Federal Hazardous Substances Labeling Act (FHSLA), Federal Register Aug. 12, 1961, p 7333-7341, Part 191 "Hazardous Substances Definitions and Procedural and Interpretative Regulations, Final Order"
- GLP compliance:
- no
Test material
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- resorcinol
- Details on test material:
- Flaked grade Resorcinol
Flaked Grade (deep, ivory colored solid) and Industrial Grade (dark brown colored solid), no purity data available.
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- physiological saline
- Amount / concentration applied:
- Concentration: 500 mg
- Duration of treatment / exposure:
- 24 hour(s)
- Number of animals:
- 6
- Details on study design:
- The irritation produced by a single contact of each material with the skin was measured by a patch-test technique on the abraded and intact skin bellies of male, albino rabbits, clipped free of fur. One-half of a gram of the material was moistened with physiological saline and applied, under one-inch-square gauze patches to three intact and three abraded areas randomly distributed over the bellies of six male, albino rabbits. The patches were secured in place by adhesive tape and the trunks of the animals were wrapped in impervious plastic films to further secure the patches and retard the evaporation of the chemical. Following a 24-hour period of exposure, during which the rabbits were confined in stocks, the patches were removed and the skin reactions were evaluated on the basis of erythema, edema, and necrosis. The exposed areas were again evaluated after 72 hours. Areas of the skin which were damaged by the material were kept under observation for a maximum period of two weeks.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 4.4
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.03
- Max. score:
- 4
- Reversibility:
- fully reversible within: 2 weeks
- Remarks on result:
- other: 48 h value was considered to be the same as the 72 h value as worst case approach
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 2 weeks
- Remarks on result:
- other: 48 h value was considered to be the same as the 72 h value as worst case approach
Any other information on results incl. tables
Flaked Grade: Not a primary irritant
Evaluation Time (hours)
Effect on skin
Erythema Edema
A. Intact B. Abraded C. intact D. Abraded
24 0.7 2.7*
1.3 3.0*
72 1.2 3.5*
1.5 3.5*
Total 1.9 6.2*
2.8 6.5*
Primary Irritation score [(A+B+C+D)/4]: 4.4
*Based upon necrotic areas being scored 4.0, the maximum
score possible, for both eythema and edema.
The contact of 0. 5 gm of the test material with the intact
and abraded areas of the skin of male, albino rabbits for a
maximum period of 24 hours produced responses, the most
severe of which were: Intact, moderate irritation; Abraded, necrosis; primary
irritation score, 4. 4 for the Flaked Grade.
In general, after 72 hours exposure, the effects of the skin
were more prevalent than at 24 hours following exposure.
After 14 days the necrotic areas were still encrusted or
scarred but other areas were free of any signs of irritation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The primary irritation score was calculated to be 4.4 for the Flaked Grade and is considered by the author to no be an irritant. When evaluated in association with EC 1272/2008 (CLP), the substance is considered a Category 2 Irritant.
- Executive summary:
A twenty four-hour, occluded application of flaked and industrial grade resorcinol at 500 mg to the bellies of male albino rabbits (strain not specified) resulted in moderate irritation on intact skin and necrosis on abraded sites with flaked grade resorcinol (Flickinger, 1976 and Koppers Company, 1962; RL=2 (provides basic data)). Industrial grade resorcinol results varied after 24 hours from slight to severe irritation of the intact areas and from severe irritation to necrosis of the abraded areas. After the 14 day recovery period the necrotic areas were either still encrusted or scarred but the other areas were free of any signs of irritation. The primary irritation scores for flaked and industrial grade resorcinol were 4.4 and 5.4, respectively
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