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EC number: 231-442-4 | CAS number: 7553-56-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study not following GLPs
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Iodine
- EC Number:
- 231-442-4
- EC Name:
- Iodine
- Cas Number:
- 7553-56-2
- Molecular formula:
- I2
- IUPAC Name:
- iodine
- Details on test material:
- - Name of test material: Iodine
- Substance type: Inorganic
- Physical state: Solid
- Analytical purity: min 99.8%
- Impurities: None relevant for classification and labelling
- Lot/batch No.: No indicated
- Expiration date of the lot/batch: Not applicable
Constituent 1
In vitro test system
- Test system:
- artificial membrane barrier model
- Justification for test system used:
- The Corrositex test is a standardized and reproducible method that can be employed to determine the potential corrosivity and the Packing Group classification of specified categories of chemical compounds under the hazardous materials transportation regulations administered by the U.S. Department of Transportation (DOT) and international dangerous goods codes. The Corrositex test predicts the in vivo corrosive potential of a chemical compound or mixture by using as an endpoint the amount of time it takes for a chemical to permeate through or destroy a synthetic biobarrier. A color change in a proprietary liquid Chemical Detection System (CDS) is used to indicate that the chemical has passed through the biobarrier.
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- The corrositex assay is a three step procedure. First, the sample is qualified to ensure that the test sample is compatible with the Corrositex system, then it is categorized according to pH, and finally it is classify based on the time the sample takes to break through the biobarrier.
Qualify: An aliquot of the sample was aded to the Chemical Detection System (CDS) reagent, and the vial was observed for any notable colour change. An observable colour change indicates that the test sample is compatible with the Corrositex system.
Categorize: The sample was categorized which determined cut-off times for the classification designation. A 10% aqueous solution of the sample was prepared, and the pH was measured. Based on the pH of a 10% solution, an aliquot was added to a respective Indicator Tube, based on the final pH of the Indicator Tube, a category was assigned to the sample (alternative method).
Classify: 500 mg of undiluted sample was added to 4 test vials containing biobarriers. A positive control was performed using 1.0 N sodium hydroxide. A negative control was also performed. The amount of time required for the test material to destroy the biobarrier was recorded and used to designate the classification. - Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- TEST MATERIAL
- Amount applied: 500 mg of undiluted sample.
VEHICLE
- Amount applied: No vehicle was used. - Number of replicates:
- 4 for test item, one negative and one positive control
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Value:
- > 65
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Non-corrosive
Any other information on results incl. tables
The results indicated that the test sample was compatible with the Corrositex assay. The sample was categorized in Category 2 (table 1)
Table 1: Summary of results of qualification and categorization step
Concentration tested: | 100% |
pH taken from 10% aqueous solution | 4.83 |
Colour in tube A/B | None |
pH taken from tube A/B | 7.03/6.65 |
Category | 2 |
The penetration time and results are presented in Table 2.
Table 2: Penetration time and results.
Corrositex time (minutes) | |
Replicate #1 | > 65 |
Replicate #2 |
> 65 |
Replicate #3 |
> 65 |
Replicate #4 |
> 65 |
Mean |
> 65 |
Positive control #1 |
17 |
Positive control #2 |
16 |
Classification | Non-corrosive |
Applicant's summary and conclusion
- Interpretation of results:
- other: Non-Corrosive
- Remarks:
- Criteria used for interpretation of results: other: Dir. 67/548/EC, GHS and UN Packing Group Classification
- Conclusions:
- The findings of the study lead to the designation of the sample as a non-corrosive substance
- Executive summary:
The test item was analyzed by the Corrositex test method to determine its corrosive potential and its classification.
The Corrositex test predicts the in vivo corrosive potential of a chemical compound or mixture by using as an endpoint the amount of time it takes for a chemical to permeate through or destroy a synthetic biobarrier. A color change in a proprietary liquid Chemical Detection System is used to indicate that the chemical has passed through the biobarrier.
The results of this study indicated that the sample was compatible with the Corrositex system and was determined to be a Category 2 sample. The results obtained from the evaluation of four replicates samples were consistent (> 65 minutes), demonstrating that a mean time of > 65 minutes was required to destroy the synthetic biobarriers. These findings lead to the classification of test item, as a Non-Corrosive material.
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