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EC number: 208-293-9 | CAS number: 520-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study reported in 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- (only basic data given)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted Feb 1987
- Deviations:
- yes
- Remarks:
- (only basic data given)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- EC Number:
- 208-293-9
- EC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- Cas Number:
- 520-45-6
- Molecular formula:
- C8H8O4
- IUPAC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Dehydroacetic acid
Test animals
- Species:
- rat
- Strain:
- other: albino
- Remarks:
- 200-300 grams body weight
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 24 h
- Housing: 5 animals of the same sex per common cage
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Doses:
- 1000, 1600, 2000, 2500, 3200, 4000, 5000 and 6400 g/kg (males)
1000, 1250, 1600, 2000, 2500, 3200, 4000, 5000 and 6400 g/kg (females) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 480 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 620 mg/kg bw
- Based on:
- test mat.
- Mortality:
- For details refer to Table 1 under "any other information on results"
- Clinical signs:
- other: All dose goups: lethargy 2000 mg/kg bw or more: gradual loss of motor control on the second day, magnified loss of motor control in further study progress, weight loss and debilitated survivors 5000 mg/kg or more: lack of motor control, hyperactive respo
Any other information on results incl. tables
Table 1: Acute oral toxicity
Dose | Mortality | Clinical signs |
[mg/kg bw] | ||
N* | N* | |
Males | ||
1000 | 0/5 | 5/5 |
1600 | 2/5 | 5/5 |
2000 | 4/5 | 5/5 |
2500 | 5/5 | 5/5 |
3200 | 5/5 | 5/5 |
4000 | 5/5 | 5/5 |
5000 | 5/5 | 5/5 |
6400 | 5/5 | 5/5 |
Females | ||
1000 | 0/5 | 5/5 |
1250 | 1/5 | 5/5 |
1600 | 3/5 | 5/5 |
2000 | 5/5 | 5/5 |
2500 | 5/5 | 5/5 |
3200 | 5/5 | 5/5 |
4000 | 5/5 | 5/5 |
5000 | 5/5 | 5/5 |
6400 | 5/5 | 5/5 |
*N = Number of animals
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 values determined were 1620 mg/kg bw for the males and 1480 mg/kg bw for the females.
- Executive summary:
An acute oral toxicity study was conducted in male and female rats. Dosages in the range 1000 to 6400 mg/kg bw were tested. The LD50 values determined were 1620 mg/kg bw for the males and 1480 mg/kg bw for the females. Clinical signs noted included: lethargy, lack of motor control, hyperactive responses, convulsions and hemorrhaging from the nose and mouth.
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