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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
96-h test on fish: LC50 > 100 mg/l
48 -h test on aquatic invertebrates: EC50 = 235 mg/l
7 -day test on aquatic plants: in progress
Additional information
As no data on target substance was available, a read across approach with Similar Substance 01 was used. Target and read across substance have exactly the same chemical structure and they only differ in the type of salification of 2 sulphonic acid groups. In particular, target substance is a sodium and potassium salt, while read across substance is a disodium salt. Moreover, the 2 substances have the same impurities profile, mainly water and inorganic salts.
Differences in the type of salification are not expected to significantly influence the physicochemical properties, thus the read across is considered as acceptable and reliable for the assessment. Details on the read across are available in section 13.
The assessement on aquatic toxicity was based on experimental studies on fish, aquatic invertebrates and plants. At 20 °C, Similar Substance 01 has a solubility in water of 26.62 g/l and a logPow of -1.8530; it is not ready biodegradable.
Short-term toxicity to fish
Upon a preliminary test, a 96 -hour study on fish was conducted as limit test with nominal concentrations of 100 and 0 mg/l. No analytical monitoring was done, thus results were expressed as nominal concentrations. Mortality was seen and allowed to identify a LC20 of 100 mg/l and a LC50 > 100 mg/l.
Such result was confirmed by another study on fish, for which no details on test procedure and results were available.
Short-term toxicity to aquatic invertebrates
Acute toxicity to daphnia magna was assessed in a 48 -hour study at concentrations up to 1000 mg/l. A preliminary test was run to select concentrations for the main assay. No analytical monitoring was done, thus results were expressed as nominal concentrations. Effects on mobility were seen and led to identify an EC50 = 235 mg/l.
Toxicity to aquatic plants other than algae
In progress.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), the threshold of classification of a substance for acute aquatic toxicity is 1 mg/l. This limit is compared with LC50 (96h ) for fish, EC50 (48h) for daphnia, EC50 (72 -96 h) for algae and EC50 (7 d) for other aquatic plants.
As for chronic toxicity, in case of lack of chronic data, the toxic potential is identified by appropriate combinations of acute toxicity data and lack of biodegradability. The threshold of classification is 100 mg/l.
Available EC50 values on fish and daphnia indicate a low aquatic toxicity of test substance, implying no classification for both acute and chronic toxicity within the CLP Regulation (EC 12727/2008). However, a final decision on classification will be drawn, once the study on aquatic plants will be available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.