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Diss Factsheets
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EC number: 411-220-5 | CAS number: 134701-20-5 CG 27-145
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The vast majority of test compound was excreted via faeces. Urinary excretion accounted for less than 9% of the administered substance. No significant bioconcentration or -accumulation was evident in any of the organs investigated.
Key value for chemical safety assessment
Additional information
One toxicokinetic study investigating the absorption, distribution and excretion of the test substance is available. In this study, the routes and rates of excretion of total radioactivity were determined after single oral doses of 50 and 1000 mg of 14C labelled test material per kg body weight to male rats. The majority of the radiolabel (92-93%) was excreted with the faeces, predominantly during the first 24 hours postdose. Urinary excretion was ≤ 9%. Excretion of radioactivity via the expired air was negligible (< 0.03%). Cumulative excretion was virtually complete within 96 h after administration (101 and 98% after the low and the high dose, respectively). The excretion half-life in faeces was shorter than in urine in all individual animals. Mean urinary excretion half-lives were 11.8 and 14.6 hours after the low and the high dose, respectively. Mean faecal excretion halflives were 9.1 and 8.6 hours for the low and high dose, respectively. There was no indication for non-linearity in the excretion kinetics over the dose range studied At 96 h postdose, the highest tissue concentration of test material was observed in the fat (2.42 and 116 mg/kg tissue at low and high dose, respectively, comprising 0.01 and 0.02% of the total applied dose only), followed by thymus, liver and kidney (overall range of 1.39-1.88 and 13.6-25.9 mg/kg tissue for low and high dose, respectively), and at the high dose by skin, gastrointestinal tract and carcass (overall range of 11.9-17.4 mg/kg tissue). The retention of the administered radiolabel was minimal. Expressed in % of the applied dose this represents only 0.25 and 0.39% for the sum of the organs for low and high dose, respectively, and 0.72 and 1.14% for the carcass for the low and the high dose, respectively. Generally, the organs and tissues examined contained less than 0.01% of the dose, except for liver (< 0.15%), and the kidney and gastrointestinal tract (< 0.03%). There were no significant differences in the pattern of distribution between the high and low dose. There was no significant bioconcentration or accumulation in any of the organs investigated.
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