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Diss Factsheets
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EC number: 217-421-2 | CAS number: 1843-05-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From Jan. 7, 1980 to Feb. 8, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study design appears to follow OECD guideline 405 (2002) with deviations. Study report states that the procedure used was described in the Proposed Guidelines of the United States Environmental Protection Agency (EPA) § 163.81-4 "Primary eye irritation study", Federal Register, Vol. 43, No. 163, August 22, 1978. The substance is an analogue with a longer alkylchain.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- -reliability scoring based on 2002 guideline
- Deviations:
- yes
- Remarks:
- -report does not specify pH or whether the test material was ground to a fine dust as recommended for solids; the eye was rinsed after 30 sec in 3/6 animals rather than the recommended 1 hr (additional deviations listed in materials and methods section)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-dodecyloxy-2-hydroxybenzophenone
- EC Number:
- 221-049-6
- EC Name:
- 4-dodecyloxy-2-hydroxybenzophenone
- Cas Number:
- 2985-59-3
- Molecular formula:
- C25H34O3
- IUPAC Name:
- [4-(dodecyloxy)-2-hydroxyphenyl](phenyl)methanone
- Details on test material:
- - Physical state: off-white powder
- Lot/batch No.: 4/79
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Bred and raised on the premises [CIBA-GEIGY Limited (Exp. Toxicology Sisseln GU 2.1, Basle, Switzerland)]
- Age at study initiation: adult, exact age not reported
- Weight at study initiation: 2 to 3 kg
- Housing: Housed individually in metal cages
- Diet (e.g. ad libitum): Standard rabbit food - NAFAG, No. 814, Gossau SG, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: Minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 10
- Photoperiod (hrs dark / hrs light): 14 hrs dark/10 hrs light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Duration of treatment / exposure:
- Single exposure
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 males and 3 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): In 3 of the 6 rabbits approximately 30 seconds after treatment the treated eye was flushed with 10 mL of physiological saline.
- Time after start of exposure: Approximately 30 seconds after treatment (in 3 of the 6 rabbits)
SCORING SYSTEM: Same scale as the one provided in the OECD guideline, with the exception of 1 criteria (changes related to discharge were included in addition to the other parameters evaluated)
TOOL USED TO ASSESS SCORE: slit lamp (The eye irritation was appraised with a slit-lamp on day 1, 2, 3, 4, and 7 and was scored for each individual rabbit).
Calculation of the primary eye irritation:
The mean reaction scores for cornea, iris, and conjunctiva observed after 1, 2, 3, 4, and 7 days were summed up and the sum divided by 5. This procedure was carried out separately for unrinsed (A) and rinsed (B) eyes respectively.
Index:
0 - 10 = minimal
11 - 25 = slight
26 - 55 = moderate
56 - 84 = marked
above 84 = extreme
The ratio R = A : B indicates the effect of rinsing the eyes approximately 30 seconds after instillation of the compound.
< 1 = rinsing increased the effect of the compound
1 = no effect
1.1 – 1.5 = practically no effect
1.6 – 2 = littler but assessable effect
2.1 – 4 = good effect
4.1 – 10 = very good effect
> 10 = action of the compound practically abolished
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- (for both rinsed and unrinsed eyes)
- Basis:
- mean
- Time point:
- other: 1, 2, 3, 4, and 7 days
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Remarks:
- (for both rinsed and unrinsed eyes)
- Basis:
- mean
- Time point:
- other: 1, 2, 3, 4, and 7 days
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- (for both rinsed and unrinsed eyes)
- Basis:
- mean
- Time point:
- other: 1, 2, 3, 4, and 7 days
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Conjunctivae score includes observations on redness, chemosis, and discharge
- Irritant / corrosive response data:
- The substance was found to cause no irritation when applied to the rabbit eye mucosa. The primary irritation index for unrinsed and rinsed eyes was 0.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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