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Diss Factsheets
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EC number: 202-453-1 | CAS number: 95-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- data not available
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- DNA-damaging activity in vivo and bacterial mutagenicity of sixteen aromatic amines and azo-derivatives, as related quantitatively to their carcinogenicity
- Author:
- Parodi S, Taningher M, Russo P, Pala M, Tamaro M & Monti-Bragadin C
- Year:
- 1 981
- Bibliographic source:
- Carcinogenesis 2 (12): 1317-26
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The substance was administered intraperitonealy to a group of experimental animals at one of the defined doses, a series of doses increasing serially by a constant factor usually < 2.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 98-80-7
- IUPAC Name:
- 98-80-7
- Reference substance name:
- 4-methyl-m-phenylenediamine
- EC Number:
- 202-453-1
- EC Name:
- 4-methyl-m-phenylenediamine
- Cas Number:
- 95-80-7
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 4-methylbenzene-1,3-diamine
- Details on test material:
- - Name of test material (as cited in study report): 2,4-Diaminotoluene from E. Merck, Darmstadt,GFR.
- Analytical purity: 96%
- Molecular Weight: 122.19
No other data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Data not available
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- None
- Doses:
- A series of doses increasing serially by a constant factor usually < 2 was used.
- No. of animals per sex per dose:
- 4 males per dose levels
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 5 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- Other examinations performed: none - Statistics:
- The LD50 was calculated according to the method of Weil (1952), only after the doses given were sufficient to obtain both 0% and 100% mortality.
Weil C.S. 1952. Tables for convenient calculation of median effective dose (LD50 or ED50) and instructions in their use. Biometrics, 8, 249-263.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 147 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- None
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this test, LD50 is 147 mg/kg bw.
- Executive summary:
Parodi at al.(1981) investigated to demonstrated for sixteen compounds a qualitative correlation with carcinogenic activity and induction of DNA damage in mamalian cells or bacterial mutagenicity. The dose level to be used in in vivo genotoxicity assay was selected from known LD50. As no data was available in litterature for 2,4 -Toluendiamine, an acute toxicity was performed. Male Sprague-Dawley rats (4 animals for each dose) were administered i.p. a series of doses of 2,4 -toluendiamine increasing serially by a constant factor. The LD50 at 5 days was calculated according to the method of Weil (1951), only after the doses given were sufficient to obtain both 0% and 100 % mortality. No data on mortality, clinical signs, body weight, or gross pathology were reported. The obtained LD50 is 147 mg/kg bw. Because of documentation insufficient for assessment, this data was classified unreliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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