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Diss Factsheets
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EC number: 204-596-5 | CAS number: 123-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Repeated dose toxicity:
oral: no valid data available
dermal: no data available
inhalation: NOAEC: 0.54 mg/L air for systemic toxicity; NOEC: 0.14 mg/L air for peroxisome proliferation
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 540 mg/m³
Additional information
Oral:
No valid data for the evaluation of the oral repeated dose toxicity available.
Dermal:
No valid data for the evaluation of the dermal repeated dose toxicity available.
Inhalation:
An inhalation repeated dose study was performed according to OECD TG 412 (BIBRA, 1997; Val. 2). Animals were exposed to 0.134, 0.536 and 1.34 mg/L air for 6 h/day on 5 days/week for 28 days. Treatment-related clinical findings were limited to transient porphyrin accumulation in the eyes in the high dose group. In the high dose group reduced body weights were observed in females on days 17 and 28, and in males of the same group over the duration of the study. A decreased percentage of lymphocytes and an increased percentage of neutrophils were observed in males and females in the high dose group. The clinical chemistry examinations of serum revealed decreased levels of fasting glucose and plasma cholesterol and increased levels of triglycerides in rats of the high dose group. Plasma alkaline phosphatase activity was increased in all treated groups. Gross examination at necropsy did not reveal any changes attributable to 2-ethylhexanal. Animals in the high dose group showed decreased thymus weight and increased weight of testes, heart (males), liver and lungs. The adrenal gland weights were increased in high dose males, and showed a dose-dependent increase in all treated groups of females. The mid- and high-dose groups of females showed dose-related increases in kidney weights, and this was also seen in males of the high dose group.
Electron microscopic and biochemical investigations were also conducted to investigate the induction of peroxisome proliferation in the rat liver. Although 2-ethylhexanal appeared to have the potential to induce small changes in peroxisomal and microsomal fatty acid oxidizing enzymes in the liver, the effects are much less marked than those produced by di(2- ethylhexyl)phthalate (DEHP, the concurrent positive control).
Justification for classification or non-classification
No classification according to repeated dose toxicity studies.
A NOAEC for overall effects/systemic toxicity of 102.2 ppm/0.54 mg/L air can be derived. The exposure of rats to 2-ethylhexanal produced small effects on relative liver weight at 25.5 ppm/0.14 mg/L air and on the markers of hepatic peroxisome proliferation measured, this dose can be used as a NOEC for peroxisome proliferation.
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