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EC number: 283-392-8 | CAS number: 84605-29-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study; well documented study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts
- EC Number:
- 283-392-8
- EC Name:
- Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts
- Cas Number:
- 84605-29-8
- Molecular formula:
- Not applicable
- IUPAC Name:
- Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazelton Research Products Inc.
- Weight at study initiation: 4038 to 5232 grams.
- Housing: Individual suspended mesh-bottom cages.
- Acclimation period: minimum of 6 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 66-69F.
- Humidity (%):32-50%.
- Photoperiod (hrs dark / hrs light): 12 hours light/ 12 hours dark.
IN-LIFE DATES: February 25 1993 through March 29, 1993
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: mineral oil
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
In group 1 the test material was dosed (0.5ml/site) as received. In group 2, there were four intact sites per rabbit. Each rabbit was administered single applications (0.5ml/site) of the test material at at 6.25, 12.5, 25, and 50% concentration in mineral oil . - Duration of treatment / exposure:
- The test substance was administered once per site and remained in contact with the skin for 4 hours followed by removal with disposable paper towels moistened with light, white mineral oil.
- Observation period:
- The skin was examined and graded for dermal reaction at 24 and 72 h following patch removal.
- Number of animals:
- 12 females
- Details on study design:
- TEST SITE
On the day prior to dosing, the hair was removed from the backs of the rabbits using an Oster small animal clipper. Each 0.5 milliliter dose was applied under a 2-ply 1" x 1" gauze patch, overwrapped with a gauze binder and secured with Dermiform Tape. Plastic restraint collars were applied and remained on the animals for the duration of the exposure period (4 hours). Following the exposure period, residual test substance was removed with
disposable paper towels moistened with light, white mineral oil.
SCORING SYSTEM: Dermal Irritation was graded in accordance with the Draize method of scoring.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: as supplied concentration/undiluted
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: as supplied concentration/undiluted
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 1.4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 6.25% in mineral oil
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 0.08
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 6.25% in mineral oil
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 2.2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 12.5% in mineral oil
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 0.6
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 12.5% in mineral oil
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 2.6
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 25% in mineral oil
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 0.9
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 25% in mineral oil
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 2.83
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 50% in mineral oil
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 1.2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 50% in mineral oil
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 1.5
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 6.25% in mineral oil
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 2.7
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 12.5% in mineral oil
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 3.5
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 25% in mineral oil
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 4
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: 50% in mineral oil
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 4.25
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: as supplied concentration/undiluted
- Irritant / corrosive response data:
- Undiluted test material induced moderate erythema and very slight to slight edema on all rabbits. There were no other dermal findings.
The 6.25% concentration of the test material induced very slight to slight erythema on all rabbits and very slight edema on one rabbit. There were no other dermal findings.
The 12.5 % concentration of the test material induced slight to moderate erythema and very slight edema on all animals. There were no other dermal findings.
The 25 % concentration of the test material induced slight to moderate erythema and very slight to slight edema on all animals. There were no other dermal findings.
The 50 % concentration of OS# 29802K induced moderate erythema and very slight to slight edema on all rabbits. There were no other dermal findings.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Based on the results of this study, the test substance would be classified as a Category 2 in accordance with the classification system of GHS.
- Executive summary:
The primary dermal irritation potential of the test material was evaluated in this study with New Zealand White rabbits. There were two groups of six rabbits. In Group 1, single 0.5 milliliter doses of undiluted test material were applied to a single site on each animal's back. In Group 2, single 0.5 milliliter doses of the test material at concentrations of 6.25, 12.5, 25 and 50% (weight to volume in mineral oil) were applied to four distinct application sites on each animal's back; each animal received a single dose of each concentration.Alldoses were applied under semi-occlusive dressing for a four hour exposure period. At completion of exposure the bandages were removed and the sites washed with light, white mineral oil and disposable paper towels. Application sites were evaluated in accordance with the method of Draize at approximately 24 and 72 hours after patch removal.
There were no deaths or significant body weight changes during the study period.
In Group 1, thePrimaryIrritation Index was calculated to be 4.3 for sites treated with undiluted test material.
In Group 2, Primary Irritation Indices of 1.5, 2.8, 3.5 and 4.0 were calculated for 6.25, 12.5, 25 and 50% w/v concentrations of the test material in mineral oil, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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