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EC number: 271-013-9 | CAS number: 68513-69-9 A complex residuum from the distillation of the products from a steam-cracking process. It consists predominantly of aromatic and unsaturated hydrocarbons having carbon numbers greater than C7 and boiling in the range of approximately 101°C to 555°C (214°F to 1030°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Residues (petroleum), steam-cracked
- EC Number:
- 265-193-8
- EC Name:
- Residues (petroleum), steam-cracked
- Cas Number:
- 64742-90-1
- IUPAC Name:
- 64742-90-1
- Reference substance name:
- Carbon Black-DSM Roetolie
- IUPAC Name:
- Carbon Black-DSM Roetolie
- Details on test material:
- - Name of test material (as cited in study report): Carbon Black-DSM Roetolie
- Batch number: UN:2810, batch number. 16-5-89
- Substance type: Mixture of high boiling aromatic hydrocarbons
- Physical state: dark brown viscous liquid
- Analytical purity: not applicable
- Storage: room temperature
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: ENKI-Konijnenfarm, Someren, the Netherlands
- Age at study initiation: young adult
- Sex: male
- Weight at study initiation: 2700-2870 g
- Housing: individually in suspended, galvanized cages, fitted with a wire mesh floor and front
- Diet: standard laboratory rabbit diet ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 6 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19 ± 3°C
- Humidity: at least 40%
- Air changes (per hr): approx. 10
- Photoperiod: natural day/night cycle
IN-LIFE DATES: From: 22 May 1989 To: 25 May 1989
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- Single instillation
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
SCORING SYSTEM: Corneal opacity on a 0-4 scale, iritis on a 0-2 scale, conjunctival redness on a 0-3 scale, conjunctival chemosis on a 0-4 scale
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: no corneal effects
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: no iridial effects
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.4
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: minimal redness in 3 animals 1- 24 hours and 1 animal at 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: minimal chemosis in 3 animals 1- 24 hours and 1 animal at 48 hours
- Irritant / corrosive response data:
- After 1 hour slight redness with or without slight swelling of the conjunctivae. At 24 hours slight redness and slight swelling of the conjunctivae. At 48 hours the eye effects had cleared completely in two of the three rabbits, whereas slight redness and slight swelling of the conjunctivae were observed in the third rabbit. All irritation had cleared by 72 hours.
- Other effects:
- The test substance adhered to the hair surrounding the eye in all 3 rabbits.
Any other information on results incl. tables
Eye irritation scores of Carbon Black-DSM Roetolie
Time |
Cornea |
Iris |
Conjunctiva |
||||||||||
|
|
|
|
Redness |
Chemosis |
||||||||
|
Animal number |
63 |
73 |
74 |
63 |
73 |
74 |
63 |
73 |
74 |
63 |
73 |
74 |
after 1 hour |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
1 |
1 |
0 |
0 |
|
after 24 hours |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
1 |
1 |
1 |
1 |
|
after 48 hours |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
1 |
|
after 72 hours |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
mean scores 24-72h |
0 |
0 |
0 |
0 |
0 |
0 |
0.3 |
0.3 |
0.7 |
0.3 |
0.3 |
0.7 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Carbon Black-DSM Roetolie is not irritating to eyes.
- Executive summary:
Eye irritation potential of carbon black-DSM Roetolie (CAS 64742-90-1) was determined in a group of three albino rabbits.
There was no evidence of damage to the cornea or iris throughout the study. Conjunctival redness and chemosis was seen from 1 hour to 48 hours after application. Mean scores over 24, 48 and 72 hours were: cornea 0, iris 0, conjunctival redness 0.4, chemosis 0.4.
Carbon black-DSM Roetolie (CAS 64742-90-1) was not irritating to the rabbit eye and does not warrant classification under Dir 67/548/EEC or GHS CLP.
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