Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-385-5 | CAS number: 106-32-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- 10 rabbits were dermally administered a single dose of the test material and observed during 14 days.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl octanoate
- EC Number:
- 203-385-5
- EC Name:
- Ethyl octanoate
- Cas Number:
- 106-32-1
- Molecular formula:
- C10H20O2
- IUPAC Name:
- ethyl octanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details were provided.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No details were provided.
- Duration of exposure:
- No details were provided.
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 10 animals in total
- Control animals:
- not specified
- Details on study design:
- No details were provided.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died during the study.
- Clinical signs:
- other: No clinical signs were observed aside from skin irritation such as redness and edema. Skin irritation: - Slight redness in 2/10; moderate redness in 4/10 - Slight edema in 1/10; moderate edema in 3/10
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 of the test item was > 5 g/kg.
- Executive summary:
In the current study a group of 10 rabbits were dermally administered a single dose of 5 g/kg. No OECD guideline was followed and the study was not GLP. The animals were observed for mortality and clinical signs during 14 days.
The acute dermal LD50 of the test item in rabbits was reported to be > 5000 mg/kg, based on 0/10 deaths at that dose.
According to the CLP legislation a substance is considered acute toxic via the dermal route when the acute toxicity estimate is =< 2000 mg/kg bodyweight. As the LD50 of the test item > 2000 mg/kg bw, the substance is not to be classified as acute toxic via the dermal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
