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Diss Factsheets
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EC number: 947-515-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The are two studies on 2,2’-(C16 -18 (evennumbered, C18 unsaturated) alkyl imino) diethanol CAS 1218787-32-6 (Formerly identified as: Ethanol, 2,2’-iminobis-, N-tallow alkyl derives CAS No 61791-44-4) available for skin corrosion/irritation: A validity 1 GLP study to OECD 404 except that weanling domestic pigs were used and therefore not prefered for classification purposes, and a validity 2 GLP OECD 404 study in rabbits that show corrosion after a 4 hour exposure OECD/GHS Category 1C. There is no data on eye irritation but this in not a concern as the corrosive classification for the skin will also be applied to the eyes via the hazard statement.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are two studies available for skin corrosion/irritation on 2,2’-(C16 -18 (evennumbered, C18 unsaturated) alkyl imino) diethanol CAS 1218787-32-6 (Formally identied as: Ethanol, 2,2’-iminobis-, N-tallow alkyl derives CAS No 61791-44-4). The first study is a validity one GLP study carried out to OECD 404 in 2002, however rather than use of rabbits the study was carried out using weanling domestic pigs. No mortality or clinical signs of toxicity were observed during the 168-hour observation period. Scab formation was observed on all three animals beginning at the 48 hour observation period and extending to the 168 hour observation period (slight/moderate scabbing). Exfoliation (slight/moderate) was observed on two of the three animals beginning at the 120 hour observation period extending to the 168 hour observation period. Based on this study Ethanol, 2,2’-iminobis-, N-tallow alkyl derives CAS No 61791-44-4 can be classified as a mild irritant to the skin (Category 3 according to OECD-GHS.
The second study that is available is a CESIO validity 2 study but done to GLP following OECD guideline 404. The study was performed to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit. The method used followed the recommendations of the OECD Guidelines for Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion" and Method B4 of the EC. A single 4 -hour, semi-occluded application of the test material to the intact skin of six rabbits produced severe dermal responses. Scar tissue, indicative of dermal corrosion was noted in 5 out of 6 rabbits 14 days after application. The Ethanol, 2,2’-iminobis-, N-tallow alkyl derives was therefore classified as corrosive (Category 1C) to the rabbit skin, according to OECD/GHS criteria.
Justification for classification or non-classification
The CESIO study while validity 2 was used as the basis for classification as it uses the OECD guideline recommended species of the rabbit and therefore the results are comparable with other testing done for classification purposes. After a 4 hour application scar tissue, indicative of dermal corrosion was noted in 5 out of 6 rabbits 14 days after application. 2,2’-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol was therefore classified as corrosive (Category 1C) to the rabbit skin, according to OECD/GHS criteria.
There are no studies on eye irritation with 2,2’-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol but due to the corrosive nature to the skin of the substance it is not ethical to carry out this animal study. The corrosive classification of the 2,2’-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol and the required risk management methods to avoid eye contact, so the lack of an eye irritation study will not affect the safe handling of the substance. 2,2’-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol will be considered to be corrosive to eyes based on the effects on the skin as the GHS/CLP phases for skin irritation also includes serious eye damage.
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