Azelaic acid, calcium salt (1:1)

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02 January - 10 April 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

March 04, 2016.

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

March 23, 2006

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: isothermal thermogravimetry

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material:
13502 or 13995
- Expiration date of the lot/batch:
19 December 2020

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
At room temperature

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

< 0 Pa

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

< 0 Pa

At the start of the experiment a significant weight loss was observed which was due to evaporation of impurties.

The weight loss of the test item at 200°C - 220°C was lower than the weight loss of the reference substance at the same temperatures. According to this, the vapour pressure of the test item was determined to be lower than that of benzo(ghi)perylene. The results of the vapour pressure for the test item at 20°C and 25°C are given in Table 3.

Table 2          Results of the Vapour pressure Isothermal TGA Analysis with the Test Item

Temperature [°C]	Weight loss [µg/min]	νT [g/cm^2/h]	logνT	logPT	PT [Pa]
200	0.233333	2.79 x 10^-5	-4.56	-0.71	0.20
	0.246146	2.94 x 10^-5	-4.53	-0.68	0.21
210	0.317458	3.79 x 10^-5	-4.42	-0.54	0.29
	0.322710	3.85 x 10^-5	-4.41	-0.53	0.30
220	0.500590	5.98 x 10^-5	-4.22	-0.29	0.52
	0.489311	5.84 x 10^-5	-4.23	-0.30	0.50

Table 3         Vapour pressure of the Test Item

	20°C		25°C
	[Pa]	[mm Hg]	[Pa]	[mm Hg]
Test item	< 1.3x10^-8	< 1.0x10^-10	< 5.5x10^-8	< 4.1x10^-10

Conclusions:

The vapour pressure of the test item at 20°C and 25°C was <1.3 E-8 Pa and <5.5 E-8, respectively.

Executive summary:

The study to determine the vapour pressure of calcium azelate was conducted according to OECD 104 and EU A.4 guidelines using the isothermal thermogravimetric (TGA) effusion method. The vapour pressure of the test item was <1.3E-8 Pa and <5.5E-8 at 20°C and 25°C, respectively.

The study was conducted according to standard guidelines and is GLP-compliant and therefore is considered as reliable without restrictions.

Description of key information

The vapour pressure of the test item was <1.3E-8 Pa and <5.5E-8 at 20°C and 25°C, respectively.

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C

Additional information

The study to determinethe vapour pressure of calcium azelate was conducted according to OECD 104 and EU A.4 guidelines using the isothermal thermogravimetric (TGA) effusion method (Volic 2019).

The study was conducted according to standard guidelines and is GLP-compliant and therefore is considered as reliable without restrictions (Klimisch 1).